Across TCGA cell cohorts, MT-CO1 mutation is significantly associated with the RNA expression of many other genes, with 151 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible MT-CO1-associated genes across cancer lineages are OR2AK2, INSRR, and SMIM21. Each is linked with MT-CO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MT-CO1-to-partner and partner-to-MT-CO1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MT-CO1→partner) and Y-score (partner→MT-CO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2AK2 →	+0.017	+3.947	.009	.004	3	2
LUNG_NSCLC_LUAD	INSRR →	+0.046	+4.142	<.001	.008	3	2
CNS	SMIM21 →	+0.088	+3.479	<.001	.009	3	2
OVARY	SCRG1 →	+0.636	+3.714	<.001	.004	3	1
OVARY	SLC6A18 →	+0.053	+3.405	<.001	.005	3	1
OVARY	OR5AK2 →	+0.158	+3.807	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 151 associations by consensus.

Exploration

MT-CO1 survival (RNA) · tumor vs normal (RNA) · all MT-CO1 data types