Across TCGA pan-cancer cohorts, MT-CO1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MT-CO1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MT-CO1 RNA is repressed in tumor relative to normal tissue. In most cancer types MT-CO1 is over-expressed in tumor, although a few such as KIRC and HNSC show the opposite, repressed pattern.
KIRC, HNSC, and COAD are the cancer types where MT-CO1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MT-CO1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.