MST1R

Across TCGA cell cohorts, MST1R mutation is significantly associated with the RNA expression of many other genes, with 862 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MST1R-associated genes across cancer lineages are MSTN, FAM149A, and PPP2R5E. Each is linked with MST1R in more than 1 cancer types. Because this analysis shows association rather than direction, both MST1R-to-partner and partner-to-MST1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSTN grouped by MST1R-low versus MST1R-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MST1R→partner) and Y-score (partner→MST1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MSTN →	+0.226	+3.383	.003	.007	3	2
LARGE_INTESTINE	FAM149A →	+1.380	+1.941	<.001	.009	3	2
LARGE_INTESTINE	PPP2R5E →	+0.456	+2.491	.003	.003	3	2
LARGE_INTESTINE	NIPSNAP1 →	+0.616	+3.321	.007	.003	3	2
LARGE_INTESTINE	MRPL42 →	+0.615	+3.257	<.001	.002	3	2
LARGE_INTESTINE	MSH4 →	+0.228	+2.242	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 862 associations by consensus.

MSTN by MST1R expression — BLOOD_Leukemia

Explore this box plot interactively →