MST1R

Across TCGA pan-cancer cohorts, MST1R RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MST1R’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MST1R RNA is repressed in tumor relative to normal tissue. In most cancer types MST1R is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, THCA, and LUAD are the cancer types where MST1R tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MST1R RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−0.725	<.001	11	view →
THCA	Male	IV	+2.520	<.001	10	view →
LUAD	Female	III,IV	+1.145	<.001	9	view →
KICH	Male	All	−1.075	<.001	9	view →
COAD	Male	II,III,IV	+0.839	<.001	9	view →
STAD	Male	All	+1.646	<.001	6	view →
UCEC	All	All	+1.504	<.001	6	view →
HNSC	Male	All	+1.207	<.001	6	view →
BRCA	All	All	+0.992	<.001	6	view →
LIHC	All	All	+0.717	<.001	5	view →
PAAD	All	All	+2.627	.002	4	view →
LUSC	All	All	−0.507	.020	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MST1R–KIRC

Open the KIRC breakdown →