Q-omics provides the consensus-scored MSC-AS1 profile across patient tissues and cancer cell-line models. MSC-AS1 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in MESO. Among the 18 cancer types available for tumor–normal comparison, MSC-AS1 is differentially expressed in 13, with the highest sampling consensus in HNSC. Additionally, MSC-AS1 RNA expression shows 18,526 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight MESO, HNSC, and TGCT as cancer lineages where MSC-AS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MSC-AS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MSC-AS1 survival associations across molecular data types. MSC-AS1 RNA expression shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MSC-AS1 RNA expression–survival associations across cancer types. High MSC-AS1 expression shows unfavorable associations in MESO, HNSC, BLCA, LIHC and STAD, but favorable associations in UCS. The MESO Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify MESO as the clearest survival context for MSC-AS1 RNA expression.
This table summarizes MSC-AS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for MSC-AS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MSC-AS1 shows lower tumor expression in THCA and UCEC and higher tumor expression in HNSC, KIRC, KIRP and COAD. The HNSC box plot shows higher MSC-AS1 RNA expression in tumor versus normal tissue (log2 FC = +1.847, t-test p < 0.001).
This table shows molecular features associated with MSC-AS1 in patient tissues and cancer cell lines. In patient samples, MSC-AS1 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set.
