MSC-AS1

Across TCGA pan-cancer cohorts, MSC-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MSC-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MSC-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MSC-AS1 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

HNSC, KIRC, and KIRP are the cancer types where MSC-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MSC-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.847	<.001	11	view →
KIRC	Female	III,IV	+1.829	<.001	11	view →
KIRP	Male	II,III,IV	+2.085	<.001	9	view →
THCA	Female	II,III,IV	−0.741	<.001	9	view →
UCEC	All	All	−1.414	<.001	6	view →
COAD	Male	IV	+0.406	.016	5	view →
LUSC	Male	All	+0.794	<.001	4	view →
LIHC	All	All	+0.647	<.001	4	view →
LUAD	All	All	+0.451	<.001	4	view →
KICH	All	All	−0.998	.002	2	view →
CHOL	All	All	+0.824	.002	2	view →
STAD	All	II,III,IV	+0.318	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MSC-AS1–HNSC

Open the HNSC breakdown →