MSC-AS1

Across TCGA pan-cancer cohorts, MSC-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated MSC-AS1 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher MSC-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MSC-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRC show a favorable association.

MESO, HNSC, and BLCA are the cancer types where MSC-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.391	0.699	<.001	107	view →
HNSC	DFS	Tertile	All	0.587	0.835	<.001	50	view →
BLCA	OS	Median	II,III,IV	0.352	0.506	.002	45	view →
LIHC	OS	Quartile	II,III,IV	0.275	0.530	.001	37	view →
STAD	OS	Median	All	0.278	0.518	.001	30	view →
UCS	DFS	Median	II,III,IV	0.535	0.152	.004	30	view →
KIRC	DFS	Tertile	All	0.888	0.699	.003	26	view →
UVM	OS	Tertile	All	0.845	0.483	.015	19	view →
CHOL	DFS	Tertile	II,III,IV	0.700	0.140	.042	15	view →
DLBC	OS	Median	IV	1.000	0.417	.013	14	view →
KIRP	DFS	Tertile	All	0.569	0.872	.005	9	view →
ACC	DFS	Quartile	All	0.913	0.347	.008	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

MSC-AS1–MESO (OS)

Open the MESO breakdown →