Across TCGA patient cohorts, MRPL21 mutation is significantly associated with the RNA expression of many other genes, with 90 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL21-associated genes across cancer lineages are MIR4285, MIR5580, and OR4K15. Each is linked with MRPL21 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL21-to-partner and partner-to-MRPL21 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL21→partner) and Y-score (partner→MRPL21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MIR4285 →	+0.658	+5.186	<.001	.007	3	1
LIHC	MIR5580 →	+0.531	+5.758	<.001	.003	3	1
UCEC	OR4K15 →	+0.085	+3.937	<.001	.001	3	1
UCEC	DEFB104B →	+0.120	+5.253	<.001	.001	3	1
CESC	OR5BB1P →	+0.048	+6.569	<.001	.001	3	1
CESC	RNA5SP35 →	+0.238	+5.201	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 90 associations by consensus.

Exploration

MRPL21 survival (RNA) · tumor vs normal (RNA) · all MRPL21 data types