MROH3P

Across TCGA patient cohorts, MROH3P mutation is significantly associated with the RNA expression of many other genes, with 1,473 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MROH3P-associated genes across cancer lineages are ZNF852, GCC1, and PLD6. Each is linked with MROH3P in more than 1 cancer types. Because this analysis shows association rather than direction, both MROH3P-to-partner and partner-to-MROH3P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF852 grouped by MROH3P-low versus MROH3P-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MROH3P→partner) and Y-score (partner→MROH3P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF852 →	+0.422	+3.609	.001	.001	3	1
UCEC	GCC1 →	+0.620	+3.354	<.001	.005	3	1
UCEC	PLD6 →	+0.617	+2.839	<.001	.001	3	1
UCEC	DGKZP1 →	+0.369	+3.377	.004	.004	3	1
UCEC	HMGB1P14 →	+0.354	+2.818	.003	.001	3	1
UCEC	F2 →	+0.807	+2.554	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,473 associations by consensus.

ZNF852 by MROH3P expression — UCEC

Explore this box plot interactively →