MROH3P

Across TCGA patient cohorts, MROH3P mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MROH3P-associated genes across cancer lineages are eEF2, EGFR_pY1068, and eIF4E. Each is linked with MROH3P in more than 1 cancer types. Because this analysis shows association rather than direction, both MROH3P-to-partner and partner-to-MROH3P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by MROH3P-low versus MROH3P-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MROH3P→partner) and Y-score (partner→MROH3P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.459	+3.169	.005	.018	3	1
UCEC	EGFR_pY1068 →	-0.367	-2.584	.001	.011	3	1
UCEC	eIF4E →	+0.217	+2.584	.027	.011	3	1
UCEC	FOXO3a_pS318_S321 →	-0.140	-3.312	.015	.010	3	1
UCEC	GAPDH →	+0.547	+2.321	.028	.034	3	1
UCEC	INPP4B →	-0.365	-2.459	.015	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

eEF2 by MROH3P expression — UCEC

Explore this box plot interactively →