MPHOSPH9

Across TCGA patient cohorts, MPHOSPH9 mutation is significantly associated with the RNA expression of many other genes, with 3,782 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPHOSPH9-associated genes across cancer lineages are FGF21, SHPK, and KRTAP21-1. Each is linked with MPHOSPH9 in more than 2 cancer types. Because this analysis shows association rather than direction, both MPHOSPH9-to-partner and partner-to-MPHOSPH9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FGF21 grouped by MPHOSPH9-low versus MPHOSPH9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPHOSPH9→partner) and Y-score (partner→MPHOSPH9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FGF21 →	+0.250	+1.346	.002	.006	3	3
BLCA	SHPK →	+0.487	+3.343	.004	.005	3	2
BRCA	KRTAP21-1 →	+0.117	+5.733	<.001	<.001	3	2
UCEC	RNA5SP423 →	+0.396	+1.444	.004	.006	3	2
LUSC	KYNUP2 →	+0.023	+4.584	<.001	.004	3	2
LUSC	RNASEH1P1 →	+1.135	+3.469	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,782 associations by consensus.

FGF21 by MPHOSPH9 expression — UCEC

Explore this box plot interactively →