MPHOSPH9

Across TCGA pan-cancer cohorts, MPHOSPH9 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MPHOSPH9’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MPHOSPH9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MPHOSPH9 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and BLCA are the cancer types where MPHOSPH9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MPHOSPH9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.898	<.001	11	view →
THCA	Female	II,III,IV	−0.872	<.001	10	view →
BLCA	Female	All	+0.952	<.001	9	view →
LUSC	Female	All	+1.057	<.001	8	view →
STAD	All	II,III,IV	+0.869	<.001	8	view →
LIHC	Male	All	+0.708	<.001	8	view →
LUAD	Male	All	+0.988	<.001	7	view →
KIRP	All	II,III,IV	+0.728	.002	7	view →
KIRC	All	All	+0.280	<.001	7	view →
BRCA	All	III,IV	+0.738	<.001	6	view →
COAD	All	II,III,IV	+0.479	<.001	6	view →
CHOL	All	All	+0.668	.007	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MPHOSPH9–HNSC

Open the HNSC breakdown →