MOB3B

Across TCGA patient cohorts, MOB3B mutation is significantly associated with the RNA expression of many other genes, with 948 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MOB3B-associated genes across cancer lineages are RNU4-58P, MIR1285-2, and RNU2-61P. Each is linked with MOB3B in more than 1 cancer types. Because this analysis shows association rather than direction, both MOB3B-to-partner and partner-to-MOB3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-58P grouped by MOB3B-low versus MOB3B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOB3B→partner) and Y-score (partner→MOB3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU4-58P →	+0.242	+4.385	<.001	.008	3	2
SKCM	MIR1285-2 →	+0.349	+4.495	<.001	.007	3	2
UCEC	RNU2-61P →	+0.313	+3.299	.004	.001	3	2
SKCM	RN7SKP60 →	+0.142	+4.884	<.001	.004	3	2
UCEC	YTHDF3-AS1 →	+0.864	+2.638	<.001	.005	3	1
UCEC	SNRPGP17 →	+0.297	+2.294	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 948 associations by consensus.

RNU4-58P by MOB3B expression — SKCM

Explore this box plot interactively →