MOB3B

Across TCGA pan-cancer cohorts, MOB3B RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated MOB3B data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MOB3B RNA is associated with better overall survival. In most high-consensus cancer types, elevated MOB3B expression acts as an unfavorable survival marker, although some lineages such as KIRC and LGG show a favorable association.

KIRC, THCA, and LGG are the cancer types where MOB3B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.774	0.479	<.001	205	view →
THCA	OS	Tertile	All	0.846	0.969	.003	44	view →
LGG	OS	Median	All	0.872	0.745	<.001	36	view →
READ	DFS	Tertile	All	0.767	0.364	.007	25	view →
KIRP	OS	Tertile	All	1.000	0.850	.024	18	view →
BRCA	DFS	Tertile	All	0.622	0.450	.003	13	view →
COAD	DFS	Tertile	All	0.780	0.626	.006	13	view →
LUAD	OS	Median	All	0.784	0.878	.013	10	view →
SARC	DFS	Quartile	All	0.362	0.162	.017	9	view →
ESCA	DFS	Tertile	All	0.547	0.373	.018	8	view →
TGCT	DFS	Quartile	All	0.602	0.884	.014	6	view →
LUSC	DFS	Quartile	III,IV	0.350	1.000	.009	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

MOB3B–KIRC (OS)

Open the KIRC breakdown →