MOB3B

Across TCGA pan-cancer cohorts, MOB3B RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MOB3B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MOB3B RNA is repressed in tumor relative to normal tissue. In most cancer types MOB3B is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and HNSC are the cancer types where MOB3B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MOB3B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.832	<.001	12	view →
THCA	Male	III,IV	−1.871	<.001	11	view →
HNSC	Female	IV	+1.833	<.001	11	view →
LUAD	Female	III,IV	−1.258	<.001	8	view →
KIRC	Female	All	+0.717	<.001	8	view →
BRCA	All	III,IV	−1.573	<.001	6	view →
LUSC	Male	All	−0.867	<.001	5	view →
LIHC	All	All	+0.723	<.001	5	view →
UCEC	All	All	−1.493	<.001	4	view →
CHOL	All	All	+2.714	<.001	3	view →
KICH	Male	III,IV	−1.802	.021	3	view →
READ	All	All	−1.472	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

MOB3B–COAD

Open the COAD breakdown →