MMP14

Across TCGA patient cohorts, MMP14 mutation is significantly associated with the RNA expression of many other genes, with 2,647 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP14-associated genes across cancer lineages are POTEB, MIR190B, and MIR548J. Each is linked with MMP14 in more than 2 cancer types. Because this analysis shows association rather than direction, both MMP14-to-partner and partner-to-MMP14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POTEB grouped by MMP14-low versus MMP14-high in ESCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP14→partner) and Y-score (partner→MMP14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	POTEB →	+0.016	+6.709	<.001	<.001	3	3
LIHC	MIR190B →	+0.413	+6.008	<.001	.002	3	2
LIHC	MIR548J →	+0.398	+5.355	<.001	.005	3	2
LIHC	RNU7-124P →	+0.625	+5.186	<.001	.007	3	2
SKCM	EIF4EP3 →	+0.091	+4.265	.001	.003	3	2
CESC	LINC02226 →	+0.044	+5.201	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,647 associations by consensus.

POTEB by MMP14 expression — ESCA

Explore this box plot interactively →