MMP14

Across TCGA pan-cancer cohorts, MMP14 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated MMP14 data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MMP14 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MMP14 expression acts as an unfavorable survival marker, although some lineages such as LAML and DLBC show a favorable association.

ACC, MESO, and BLCA are the cancer types where MMP14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.404	0.755	<.001	119	view →
MESO	OS	Median	II,III,IV	0.269	0.519	<.001	98	view →
BLCA	DFS	Tertile	All	0.332	0.617	.001	70	view →
LGG	OS	Median	All	0.358	0.533	<.001	54	view →
LUAD	OS	Quartile	All	0.750	0.870	.001	47	view →
LIHC	DFS	Median	All	0.228	0.355	.003	44	view →
HNSC	OS	Tertile	All	0.611	0.846	.001	39	view →
UVM	DFS	Tertile	All	0.432	0.841	.004	32	view →
LAML	DFS	Median	All	0.735	0.429	.001	32	view →
DLBC	OS	Tertile	III,IV	1.000	0.154	.008	29	view →
COAD	DFS	Quartile	All	0.687	0.874	.002	23	view →
UCEC	DFS	Median	III,IV	0.853	0.739	.005	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

MMP14–ACC (DFS)

Open the ACC breakdown →