Q-omics provides the consensus-scored POTEB profile across patient tissues and cancer cell-line models. POTEB expression is associated with patient survival in 4 of 34 cancer types, with the highest sampling consensus in KIRP. Additionally, POTEB RNA expression shows 901 significant pathway-activity associations, with the highest sampling consensus in LUAD. Together, these results highlight KIRP, and LUAD as cancer lineages where POTEB shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes POTEB survival associations across molecular data types. POTEB RNA expression shows survival associations in the most cancer types (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

POTEB data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	4	KIRP (72)	view →

This table ranks reproducible POTEB RNA expression–survival associations across cancer types. High POTEB expression shows unfavorable associations in KIRP, ESCA, KIRC and LIHC. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for POTEB RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.176	0.885	<.001	72	view →
ESCA	OS	Tertile	All	0.198	0.872	.003	36	view →
KIRC	DFS	Tertile	III,IV	0.063	0.750	<.001	36	view →
LIHC	DFS	Tertile	All	0.101	0.543	.044	18	view →

Pink = unfavorable, green = favorable. all 4 lineages →

POTEB-KIRP (OS)

Kaplan–Meier survival curve for POTEB RNA expression in KIRP: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with POTEB in patient tissues and cancer cell lines. In patient samples, POTEB shows the broadest associations at the RNA and protein expression levels, with LUAD recurring as the lineage with the largest associated feature set. In cancer cell lines, POTEB RNA and mutation anchors are most strongly linked to RNA-expression features, especially in UPPER_AERODIGESTIVE_TRACT, while CRISPR and shRNA rows add functional-dependency signals in STOMACH and LUNG_NSCLC_LUSC.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
Function (RNA)	901	LUAD (406)	view →
RNA	867	PRAD (309)	view →

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼shRNA
shRNA	1,620	UPPER_AERODIGESTIVE_TRACT (195)	view →
CRISPR	1,308	STOMACH (135)	view →
▼RNA
RNA	717	LUNG_NSCLC_LUSC (300)	view →
Mutation	123	LUNG_SCLC (37)	view →