POTEB

Across TCGA cell cohorts, POTEB RNA expression is significantly associated with the mutation status of many other genes, with 123 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible POTEB-associated genes across cancer lineages are SYNE2, MT-ND4, and PYGL. Each is linked with POTEB in more than 1 cancer types. Because this analysis shows association rather than direction, both POTEB-to-partner and partner-to-POTEB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYNE2 grouped by POTEB-low versus POTEB-high in BONE.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POTEB→partner) and Y-score (partner→POTEB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SYNE2 →	+4.169	+0.010	.008	<.001	3	2
STOMACH	MT-ND4 →	+4.285	+0.005	.007	<.001	3	2
LUNG_NSCLC_LUAD	PYGL →	+3.813	+0.006	.001	<.001	3	2
BLOOD_Leukemia	DROSHA →	+3.507	+0.013	.004	<.001	3	2
SOFT_TISSUE	GRIK5 →	+4.369	+0.053	.008	<.001	3	1
SOFT_TISSUE	GBP3 →	+4.369	+0.053	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 123 associations by consensus.

SYNE2 by POTEB expression — BONE

Explore this box plot interactively →