POTEB

Across TCGA patient cohorts, POTEB RNA expression is significantly associated with the go_rna of many other GO terms, with 901 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible POTEB-associated GO terms across cancer lineages are Telomere maintenance, Negative regulation of protein-containing complex assembly, and Response to topologically incorrect protein. Each is linked with POTEB in more than 1 cancer types. Because this analysis shows association rather than direction, both POTEB-to-partner and partner-to-POTEB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Telomere maintenance grouped by POTEB-low versus POTEB-high in LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POTEB→partner) and Y-score (partner→POTEB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Telomere maintenance →	+0.052	+0.001	<.001	.003	3	2
LUAD	Negative regulation of protein-containing complex assembly →	+0.039	+0.001	.002	.001	3	2
LUAD	Response to topologically incorrect protein →	+0.037	+0.002	.004	<.001	3	2
LUAD	Cellular response to topologically incorrect protein →	+0.038	+0.001	.008	.001	3	2
LUAD	Lipoprotein biosynthetic process →	+0.036	+0.001	.001	.002	3	2
LUAD	Neuron maturation →	+0.054	+0.001	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 901 associations by consensus.

Telomere maintenance by POTEB expression — LUAD

Explore this box plot interactively →