MMD2

Across TCGA patient cohorts, MMD2 mutation is significantly associated with the RNA expression of many other genes, with 131 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMD2-associated genes across cancer lineages are FAM218BP, TRAPPC2P7, and RPL17-C18orf32. Each is linked with MMD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMD2-to-partner and partner-to-MMD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM218BP grouped by MMD2-low versus MMD2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMD2→partner) and Y-score (partner→MMD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	FAM218BP →	+0.110	+4.384	<.001	.008	3	2
BRCA	TRAPPC2P7 →	+0.203	+8.055	<.001	.007	3	2
UCEC	RPL17-C18orf32 →	+0.055	+3.546	.004	<.001	3	2
UCEC	CSGALNACT2P2 →	+0.135	+3.484	<.001	.004	3	2
LUAD	LINC02230 →	+0.220	+6.924	<.001	<.001	3	2
LUAD	IGHVII-1-1 →	+0.454	+5.197	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 131 associations by consensus.

FAM218BP by MMD2 expression — CESC

Explore this box plot interactively →