MMD2

Across TCGA pan-cancer cohorts, MMD2 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated MMD2 data layer compared with 7 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher MMD2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MMD2 expression acts as an unfavorable survival marker, although some lineages such as LGG and PAAD show a favorable association.

UVM, CESC, and ACC are the cancer types where MMD2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.403	0.852	.001	72	view →
CESC	OS	Tertile	IV	0.169	0.640	<.001	66	view →
ACC	DFS	Median	All	0.409	0.748	<.001	62	view →
UCEC	DFS	Tertile	All	0.511	0.682	<.001	54	view →
LGG	DFS	Median	All	0.817	0.659	<.001	48	view →
LIHC	OS	Tertile	All	0.327	0.535	.005	39	view →
CHOL	OS	Tertile	III,IV	0.024	0.772	.008	36	view →
PAAD	DFS	Tertile	All	0.444	0.203	.001	33	view →
THCA	OS	Tertile	IV	0.751	1.000	.014	24	view →
LAML	DFS	Tertile	All	0.610	0.305	.024	16	view →
LUAD	OS	Tertile	All	0.244	0.380	.021	15	view →
BRCA	OS	Tertile	II,III,IV	0.490	0.582	.034	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

MMD2–UVM (DFS)

Open the UVM breakdown →