MKI67

Across TCGA cell cohorts, MKI67 mutation is significantly associated with the RNA expression of many other genes, with 2,942 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MKI67-associated genes across cancer lineages are SEC13, THAP5, and LRRC40. Each is linked with MKI67 in more than 3 cancer types. Because this analysis shows association rather than direction, both MKI67-to-partner and partner-to-MKI67 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC13 grouped by MKI67-low versus MKI67-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKI67→partner) and Y-score (partner→MKI67) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SEC13 →	+0.477	+2.706	<.001	<.001	3	4
LARGE_INTESTINE	THAP5 →	+0.555	+1.808	<.001	.001	3	4
LARGE_INTESTINE	LRRC40 →	+0.460	+3.700	.002	<.001	3	4
OESOPHAGUS	OR1N2 →	+0.012	+2.857	<.001	.007	3	3
BLOOD_Leukemia	BMPR1A →	+0.979	+2.789	.009	.001	3	3
LARGE_INTESTINE	SEC24A →	+0.509	+2.459	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,942 associations by consensus.

SEC13 by MKI67 expression — LARGE_INTESTINE

Explore this box plot interactively →