Q-omics provides the consensus-scored MIR580 profile across patient tissues and cancer cell-line models. MIR580 expression is associated with patient survival in 9 of 34 cancer types, with the highest sampling consensus in CHOL. Among the 18 cancer types available for tumor–normal comparison, MIR580 is differentially expressed in 3, with the highest sampling consensus in LUSC. Additionally, MIR580 RNA expression shows 10,040 significant gene co-expression associations, with the highest sampling consensus in LAML. Together, these results highlight CHOL, LUSC, and LAML as cancer lineages where MIR580 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MIR580 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MIR580 survival associations across molecular data types. MIR580 RNA expression shows survival associations in the most cancer types (9). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MIR580 RNA expression–survival associations across cancer types. High MIR580 expression shows unfavorable associations in CHOL, DLBC, THYM, COAD and KICH, but favorable associations in BRCA. The CHOL Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify CHOL as the clearest survival context for MIR580 RNA expression.
This table summarizes MIR580 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 3. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for MIR580. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MIR580 shows higher tumor expression in LUSC, LUAD and KICH. The LUSC box plot shows higher MIR580 RNA expression in tumor versus normal tissue (log2 FC = +0.280, t-test p = .008).
This table shows molecular features associated with MIR580 in patient tissues and cancer cell lines. In patient samples, MIR580 shows the broadest associations at the RNA and protein expression levels, with LAML recurring as the lineage with the largest associated feature set.
