Q-omics provides the consensus-scored MIR4280HG profile across patient tissues and cancer cell-line models. MIR4280HG expression is associated with patient survival in 11 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, MIR4280HG is differentially expressed in 4, with the highest sampling consensus in KIRC. Additionally, MIR4280HG RNA expression shows 6,894 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight KIRC, and LSCC as cancer lineages where MIR4280HG shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MIR4280HG — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MIR4280HG survival associations across molecular data types. MIR4280HG RNA expression shows survival associations in the most cancer types (11). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MIR4280HG RNA expression–survival associations across cancer types. High MIR4280HG expression shows unfavorable associations in KIRC, ACC, THYM and LIHC, but favorable associations in LUAD and MESO. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify KIRC as the clearest survival context for MIR4280HG RNA expression.
This table summarizes MIR4280HG tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for MIR4280HG. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MIR4280HG shows lower tumor expression in COAD and higher tumor expression in KIRC, LUAD and THCA. The KIRC box plot shows higher MIR4280HG RNA expression in tumor versus normal tissue (log2 FC = +0.005, t-test p = .002).
This table shows molecular features associated with MIR4280HG in patient tissues and cancer cell lines. In patient samples, MIR4280HG shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set.
