MGA

Across TCGA patient cohorts, MGA mutation is significantly associated with the RNA expression of many other genes, with 6,763 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MGA-associated genes across cancer lineages are POLR3K, STUB1, and PTPA. Each is linked with MGA in more than 4 cancer types. Because this analysis shows association rather than direction, both MGA-to-partner and partner-to-MGA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLR3K grouped by MGA-low versus MGA-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGA→partner) and Y-score (partner→MGA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	POLR3K →	+0.595	+3.807	<.001	<.001	3	5
UCEC	STUB1 →	+0.296	+1.101	.003	<.001	3	5
UCEC	PTPA →	+0.235	+1.787	<.001	<.001	3	5
UCEC	ECHS1 →	+0.266	+1.205	.001	<.001	3	5
COAD	POLR2A →	+0.521	+2.026	.002	.005	3	4
UCEC	ZNF662 →	-0.413	-1.560	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,763 associations by consensus.

POLR3K by MGA expression — STAD

Explore this box plot interactively →