MGA

Across TCGA pan-cancer cohorts, MGA RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MGA’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MGA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MGA is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where MGA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MGA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.711	<.001	11	view →
THCA	Male	II,III,IV	−0.864	<.001	8	view →
LIHC	Female	II,III,IV	+0.785	<.001	7	view →
CHOL	Male	All	+1.473	<.001	5	view →
STAD	Male	II,III,IV	+0.855	.002	5	view →
LUSC	All	All	+0.383	<.001	5	view →
BLCA	All	All	+0.431	.023	2	view →
KIRP	Male	All	−0.375	.029	2	view →
KICH	All	All	−0.368	.032	2	view →
PRAD	All	All	+0.311	.012	2	view →
ESCA	Female	All	+0.390	.032	1	view →
LUAD	Male	All	+0.369	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MGA–HNSC

Open the HNSC breakdown →