Q-omics provides the consensus-scored MFHAS1 profile across patient tissues and cancer cell-line models. MFHAS1 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in MESO. Among the 18 cancer types available for tumor–normal comparison, MFHAS1 is differentially expressed in 12, with the highest sampling consensus in HNSC. Additionally, MFHAS1 RNA expression shows 19,377 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight MESO, HNSC, and ACC as cancer lineages where MFHAS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MFHAS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MFHAS1 survival associations across molecular data types. MFHAS1 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (6) and mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MFHAS1 RNA expression–survival associations across cancer types. High MFHAS1 expression shows unfavorable associations in MESO and ACC, but favorable associations in HNSC, LUAD, KIRC and LUSC. The MESO Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify MESO as the clearest survival context for MFHAS1 RNA expression.
This table summarizes MFHAS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 1. The strongest signals are observed in KIRC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for MFHAS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MFHAS1 shows lower tumor expression in KIRC and KICH and higher tumor expression in HNSC, STAD, LIHC and CHOL. The HNSC box plot shows higher MFHAS1 RNA expression in tumor versus normal tissue (log2 FC = +1.788, t-test p < 0.001).
This table shows molecular features associated with MFHAS1 in patient tissues and cancer cell lines. In patient samples, MFHAS1 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, MFHAS1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BREAST, while CRISPR and shRNA rows add functional-dependency signals in LIVER and BLOOD_Leukemia.
