MEX3D

Across TCGA patient cohorts, MEX3D mutation is significantly associated with the RNA expression of many other genes, with 207 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEX3D-associated genes across cancer lineages are RNU1-84P, RNU6-1228P, and GCSHP1. Each is linked with MEX3D in more than 1 cancer types. Because this analysis shows association rather than direction, both MEX3D-to-partner and partner-to-MEX3D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-84P grouped by MEX3D-low versus MEX3D-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEX3D→partner) and Y-score (partner→MEX3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU1-84P →	+0.229	+4.303	<.001	.001	3	2
HNSC	RNU6-1228P →	+0.172	+4.468	<.001	.006	3	2
HNSC	GCSHP1 →	+0.067	+5.111	<.001	<.001	3	2
UCEC	PTPRH →	+0.967	+3.480	.005	.002	3	2
COAD	RN7SL734P →	+0.418	+3.496	<.001	.008	3	2
COAD	MIR3667 →	+0.703	+3.899	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 207 associations by consensus.

RNU1-84P by MEX3D expression — HNSC

Explore this box plot interactively →