MEX3D

Across TCGA pan-cancer cohorts, MEX3D RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated MEX3D data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher MEX3D RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MEX3D expression acts as an unfavorable survival marker, although some lineages such as SCLC and UCEC show a favorable association.

MESO, ACC, and KIRP are the cancer types where MEX3D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.252	0.503	<.001	104	view →
ACC	OS	Median	All	0.775	0.961	<.001	99	view →
KIRP	DFS	Quartile	All	0.599	0.851	<.001	81	view →
LGG	DFS	Median	All	0.655	0.823	<.001	52	view →
SCLC	DFS	Median	II,III,IV	0.627	0.288	.001	43	view →
UCEC	DFS	Quartile	III,IV	0.865	0.677	.003	42	view →
UVM	DFS	Median	All	0.744	0.467	.004	35	view →
LIHC	DFS	Median	All	0.295	0.536	<.001	32	view →
SARC	OS	Median	All	0.654	0.862	<.001	24	view →
COAD	OS	Quartile	IV	0.253	1.000	.005	23	view →
PRAD	OS	Median	All	0.977	1.000	.014	18	view →
GBM	DFS	Tertile	All	0.490	0.240	.003	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

MEX3D–MESO (OS)

Open the MESO breakdown →