METTL4

Across TCGA patient cohorts, METTL4 mutation is significantly associated with the RNA expression of many other genes, with 3,506 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL4-associated genes across cancer lineages are RNU6-246P, RPL23AP60, and DUTP5. Each is linked with METTL4 in more than 2 cancer types. Because this analysis shows association rather than direction, both METTL4-to-partner and partner-to-METTL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-246P grouped by METTL4-low versus METTL4-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL4→partner) and Y-score (partner→METTL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-246P →	+0.246	+5.147	<.001	.003	3	3
HNSC	RPL23AP60 →	+0.148	+5.241	<.001	.007	3	2
LUSC	DUTP5 →	+0.110	+4.337	.004	.001	3	2
UCEC	RANBP9 →	+0.496	+2.885	<.001	<.001	3	2
UCEC	RTCB →	+0.469	+2.053	.002	.001	3	2
UCEC	POLR3H →	+0.383	+2.413	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,506 associations by consensus.

RNU6-246P by METTL4 expression — BLCA

Explore this box plot interactively →