METTL4

Across TCGA pan-cancer cohorts, METTL4 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated METTL4 data layer compared with 7 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher METTL4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated METTL4 expression acts as an unfavorable survival marker, although some lineages such as KIRC and THYM show a favorable association.

MESO, LIHC, and LGG are the cancer types where METTL4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	All	0.207	0.635	<.001	109	view →
LIHC	OS	Quartile	All	0.538	0.764	<.001	77	view →
LGG	OS	Median	All	0.733	0.887	<.001	52	view →
KIRC	DFS	Quartile	All	0.901	0.681	<.001	49	view →
KICH	OS	Median	II,III,IV	0.807	0.974	.014	49	view →
UVM	DFS	Tertile	III,IV	0.236	0.780	.007	40	view →
ACC	DFS	Quartile	All	0.267	0.735	<.001	31	view →
THYM	DFS	Quartile	II,III,IV	0.897	0.470	.002	29	view →
SCLC	DFS	Tertile	All	0.269	0.587	.009	27	view →
CESC	OS	Tertile	IV	0.188	0.713	.026	24	view →
SKCM	DFS	Quartile	II,III,IV	0.384	0.179	.004	23	view →
ESCA	OS	Tertile	IV	0.143	0.738	.024	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

METTL4–MESO (DFS)

Open the MESO breakdown →