METTL4

Across TCGA pan-cancer cohorts, METTL4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of METTL4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where METTL4 RNA is repressed in tumor relative to normal tissue. In most cancer types METTL4 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, HNSC, and LIHC are the cancer types where METTL4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in METTL4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.895	<.001	11	view →
HNSC	All	III,IV	+0.630	<.001	11	view →
LIHC	Female	II,III,IV	+0.720	<.001	9	view →
BLCA	All	III,IV	+0.507	<.001	8	view →
CHOL	Male	All	+1.801	<.001	5	view →
LUSC	All	All	+0.342	<.001	5	view →
ESCA	All	All	+1.026	.004	4	view →
KICH	Female	All	−0.989	<.001	4	view →
STAD	All	All	+0.602	<.001	4	view →
LUAD	All	All	+0.295	<.001	4	view →
KIRP	All	All	−0.329	.002	2	view →
PRAD	All	All	−0.246	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

METTL4–THCA

Open the THCA breakdown →