MED18

Across TCGA patient cohorts, MED18 mutation is significantly associated with the RNA expression of many other genes, with 191 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED18-associated genes across cancer lineages are MIRLET7A1, RAB9BP1, and SNORD82. Each is linked with MED18 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED18-to-partner and partner-to-MED18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIRLET7A1 grouped by MED18-low versus MED18-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED18→partner) and Y-score (partner→MED18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIRLET7A1 →	+0.534	+4.072	.001	.005	3	2
SKCM	RAB9BP1 →	+0.047	+4.385	.002	.008	3	2
UCEC	SNORD82 →	+0.954	+3.677	<.001	<.001	3	2
SKCM	VN1R88P →	+0.099	+4.614	<.001	.006	3	1
SKCM	ZNF723 →	+0.418	+4.049	<.001	.005	3	1
SKCM	GOLGA2P9 →	+0.024	+4.287	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 191 associations by consensus.

MIRLET7A1 by MED18 expression — SKCM

Explore this box plot interactively →