MED18

Across TCGA pan-cancer cohorts, MED18 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MED18’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where MED18 RNA is repressed in tumor relative to normal tissue. In most cancer types MED18 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, LIHC, and THCA are the cancer types where MED18 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MED18 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.402	<.001	11	view →
LIHC	Female	II,III,IV	+0.661	<.001	9	view →
THCA	Male	IV	−0.623	<.001	7	view →
BRCA	All	All	+0.230	<.001	6	view →
BLCA	All	All	+0.550	.005	5	view →
LUAD	All	All	+0.311	<.001	5	view →
STAD	All	II,III,IV	+0.517	<.001	4	view →
CHOL	All	All	+0.736	<.001	3	view →
UCEC	All	IV	−0.775	.033	2	view →
READ	All	III,IV	−0.285	.014	2	view →
HNSC	All	All	+0.256	.038	2	view →
LUSC	All	All	+0.200	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MED18–KICH

Open the KICH breakdown →