MCM3

Across TCGA cell cohorts, MCM3 mutation is significantly associated with the RNA expression of many other genes, with 115 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MCM3-associated genes across cancer lineages are LALBA, TBL1Y, and OR10A4. Each is linked with MCM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCM3-to-partner and partner-to-MCM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LALBA grouped by MCM3-low versus MCM3-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM3→partner) and Y-score (partner→MCM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	LALBA →	+0.019	+4.786	<.001	.001	3	1
PANCREAS	TBL1Y →	+0.005	+4.614	<.001	.004	3	1
LARGE_INTESTINE	OR10A4 →	+0.056	+2.938	<.001	.007	3	1
LARGE_INTESTINE	LRRC3C →	+0.253	+3.099	.001	.004	3	1
LARGE_INTESTINE	TBC1D3 →	+0.078	+3.103	<.001	.004	3	1
OVARY	CST8 →	+0.016	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 115 associations by consensus.

LALBA by MCM3 expression — PANCREAS

Explore this box plot interactively →