MCM3

Across TCGA pan-cancer cohorts, MCM3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MCM3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MCM3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MCM3 is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

COAD, HNSC, and BLCA are the cancer types where MCM3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MCM3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+1.612	<.001	12	view →
HNSC	Male	All	+1.265	<.001	12	view →
BLCA	Female	III,IV	+1.242	<.001	10	view →
KIRP	All	II,III,IV	+1.013	<.001	10	view →
LIHC	Female	II,III,IV	+2.175	<.001	9	view →
STAD	Male	II,III,IV	+1.750	<.001	9	view →
LUAD	Male	III,IV	+1.276	<.001	9	view →
LUSC	Female	All	+1.500	<.001	8	view →
KICH	Female	II,III,IV	−1.517	<.001	6	view →
BRCA	All	III,IV	+0.849	<.001	6	view →
UCEC	All	II,III,IV	+0.824	.002	6	view →
CHOL	Male	All	+3.746	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MCM3–COAD

Open the COAD breakdown →