MCM3

Across TCGA pan-cancer cohorts, MCM3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated MCM3 data layer compared with 8 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher MCM3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MCM3 expression acts as an unfavorable survival marker, although some lineages such as OV and KIRC show a favorable association.

MESO, ACC, and OV are the cancer types where MCM3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Tertile	All	0.247	0.465	.001	112	view →
ACC	OS	Median	II,III,IV	0.745	0.943	<.001	98	view →
OV	OS	Quartile	All	0.771	0.626	.005	82	view →
LIHC	DFS	Median	All	0.436	0.643	<.001	80	view →
KICH	OS	Quartile	II,III,IV	0.380	1.000	<.001	64	view →
LGG	DFS	Median	All	0.655	0.818	<.001	54	view →
SARC	DFS	Median	All	0.534	0.684	<.001	43	view →
KIRC	DFS	Quartile	All	0.759	0.502	.008	31	view →
BRCA	OS	Median	IV	0.318	0.769	.002	29	view →
SCLC	DFS	Tertile	II,III,IV	0.587	0.220	.006	28	view →
KIRP	DFS	Median	IV	0.036	0.528	.001	25	view →
CHOL	DFS	Quartile	All	0.154	0.726	.001	25	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

MCM3–MESO (DFS)

Open the MESO breakdown →