MCL1

Across TCGA patient cohorts, MCL1 mutation is significantly associated with the RNA expression of many other genes, with 2,200 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCL1-associated genes across cancer lineages are ZNF123P, IGLVIV-53, and RNU6-376P. Each is linked with MCL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCL1-to-partner and partner-to-MCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF123P grouped by MCL1-low versus MCL1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCL1→partner) and Y-score (partner→MCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	ZNF123P →	+0.045	+6.569	<.001	.001	3	2
SKCM	IGLVIV-53 →	+0.094	+7.816	<.001	.008	3	2
UCEC	RNU6-376P →	+0.304	+3.453	<.001	.003	3	2
BLCA	MIR4654 →	+0.450	+5.444	<.001	.002	3	2
BRCA	MIR4708 →	+0.570	+7.731	<.001	.009	3	1
CESC	RPS26P30 →	+0.153	+5.812	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,200 associations by consensus.

ZNF123P by MCL1 expression — CESC

Explore this box plot interactively →