MCL1

Across TCGA pan-cancer cohorts, MCL1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated MCL1 data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MCL1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MCL1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and SCLC show a favorable association.

ACC, UVM, and KIRP are the cancer types where MCL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.164	0.710	<.001	97	view →
UVM	DFS	Tertile	All	0.243	0.739	<.001	90	view →
KIRP	OS	Median	III,IV	0.177	0.706	<.001	69	view →
SKCM	OS	Tertile	All	0.408	0.245	<.001	66	view →
LGG	OS	Median	All	0.854	0.936	<.001	46	view →
SCLC	DFS	Tertile	All	0.767	0.480	.001	35	view →
PAAD	OS	Quartile	All	0.447	0.795	.001	30	view →
OV	OS	Median	III,IV	0.269	0.357	.006	30	view →
UCS	DFS	Median	IV	0.952	0.473	.018	24	view →
LUSC	DFS	Tertile	II,III,IV	0.543	0.888	.002	20	view →
LUAD	DFS	Quartile	III,IV	0.315	0.627	.018	20	view →
KIRC	OS	Quartile	All	0.738	0.559	.011	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

MCL1–ACC (DFS)

Open the ACC breakdown →