RNA, U6 small nuclear 376, pseudogeneGenealiases: []
Q-omics provides the consensus-scored RNU6-376P profile across patient tissues and cancer cell-line models. RNU6-376P expression is associated with patient survival in 11 of 34 cancer types, with the highest sampling consensus in BLCA. Among the 18 cancer types available for tumor–normal comparison, RNU6-376P is differentially expressed in 3, with the highest sampling consensus in LUAD. Additionally, RNU6-376P RNA expression shows 6,351 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight BLCA, LUAD, and STAD as cancer lineages where RNU6-376P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RNU6-376P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RNU6-376P survival associations across molecular data types. RNU6-376P RNA expression shows survival associations in the most cancer types (11). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RNU6-376P RNA expression–survival associations across cancer types. High RNU6-376P expression shows unfavorable associations in HNSC, THCA, KIRC and LUSC, but favorable associations in BLCA and ESCA. The BLCA Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .005). Together, the overview and detailed table identify BLCA as the clearest survival context for RNU6-376P RNA expression.
This table summarizes RNU6-376P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 3. The strongest signals are observed in LUAD for RNA.
This table ranks reproducible tumor–normal expression differences for RNU6-376P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RNU6-376P shows lower tumor expression in LUAD and LUSC and higher tumor expression in KIRC. The LUAD box plot shows higher RNU6-376P RNA expression in normal versus tumor tissue (log2 FC = −0.385, t-test p < 0.001).
This table shows molecular features associated with RNU6-376P in patient tissues and cancer cell lines. In patient samples, RNU6-376P shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
