Across TCGA pan-cancer cohorts, RNU6-376P RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNU6-376P’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RNU6-376P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6-376P is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, KIRC, and LUSC are the cancer types where RNU6-376P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-376P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	−0.385	<.001	5	view →
KIRC	Male	II,III,IV	+0.077	.021	4	view →
LUSC	All	All	−0.201	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: RNU6-376P RNA expression & survival · all RNU6-376P data types