MBOAT7

Across TCGA patient cohorts, MBOAT7 mutation is significantly associated with the RNA expression of many other genes, with 706 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MBOAT7-associated genes across cancer lineages are IGHD3-16, IGHD2-15, and UBTFL11. Each is linked with MBOAT7 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBOAT7-to-partner and partner-to-MBOAT7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD3-16 grouped by MBOAT7-low versus MBOAT7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBOAT7→partner) and Y-score (partner→MBOAT7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHD3-16 →	+1.127	+1.873	<.001	.001	3	2
CESC	IGHD2-15 →	+1.522	+3.751	<.001	<.001	3	2
CESC	UBTFL11 →	+0.030	+2.774	.001	.008	3	2
BLCA	H3P15 →	+0.128	+5.017	.003	.002	3	2
HNSC	MIR1277 →	+0.493	+4.736	<.001	.007	3	2
BRCA	ZNF839P1 →	+0.138	+5.122	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 706 associations by consensus.

IGHD3-16 by MBOAT7 expression — UCEC

Explore this box plot interactively →