MBOAT7

Across TCGA pan-cancer cohorts, MBOAT7 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of MBOAT7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MBOAT7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MBOAT7 is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

HNSC, LIHC, and BLCA are the cancer types where MBOAT7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MBOAT7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.146	<.001	11	view →
LIHC	Female	II,III,IV	+1.401	<.001	9	view →
BLCA	All	III,IV	+1.056	.002	9	view →
LUAD	Female	III,IV	+1.005	<.001	9	view →
THCA	Female	II,III,IV	+0.816	<.001	9	view →
KIRP	All	II,III,IV	+0.986	.001	8	view →
LUSC	All	II,III,IV	+0.789	<.001	7	view →
BRCA	All	III,IV	+1.508	<.001	6	view →
STAD	Male	II,III,IV	+1.075	<.001	6	view →
UCEC	All	All	+1.057	<.001	6	view →
CHOL	Male	All	+2.243	<.001	5	view →
PAAD	Female	All	+1.415	.008	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

MBOAT7–HNSC

Open the HNSC breakdown →