Q-omics provides the consensus-scored MBLAC1 profile across patient tissues and cancer cell-line models. MBLAC1 expression is associated with patient survival in 17 of 34 cancer types, with the highest sampling consensus in LUAD. Among the 18 cancer types available for tumor–normal comparison, MBLAC1 is differentially expressed in 5, with the highest sampling consensus in THCA. Additionally, MBLAC1 RNA expression shows 17,845 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight LUAD, THCA, and THYM as cancer lineages where MBLAC1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MBLAC1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MBLAC1 survival associations across molecular data types. MBLAC1 RNA expression shows survival associations in the most cancer types (17), followed by mutation status (1) and mass-spec protein abundance (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MBLAC1 RNA expression–survival associations across cancer types. High MBLAC1 expression shows unfavorable associations in LUAD, ACC, READ and LGG, but favorable associations in OV and PAAD. The LUAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify LUAD as the clearest survival context for MBLAC1 RNA expression.
This table summarizes MBLAC1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for MBLAC1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MBLAC1 shows lower tumor expression in THCA and higher tumor expression in LIHC, LUSC, BRCA and CHOL. The THCA box plot shows higher MBLAC1 RNA expression in normal versus tumor tissue (log2 FC = −0.899, t-test p < 0.001).
This table shows molecular features associated with MBLAC1 in patient tissues and cancer cell lines. In patient samples, MBLAC1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, MBLAC1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in UPPER_AERODIGESTIVE_TRACT, while CRISPR and shRNA rows add functional-dependency signals in SKIN.
