mannose-binding lectin family member 3, pseudogeneGenealiases: COLEC2 · MBL
Q-omics provides the consensus-scored MBL3P profile across patient tissues and cancer cell-line models. MBL3P expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in READ. Among the 18 cancer types available for tumor–normal comparison, MBL3P is differentially expressed in 4, with the highest sampling consensus in LUSC. Additionally, MBL3P RNA expression shows 7,519 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight READ, LUSC, and LSCC as cancer lineages where MBL3P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MBL3P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MBL3P survival associations across molecular data types. MBL3P RNA expression shows survival associations in the most cancer types (21). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MBL3P RNA expression–survival associations across cancer types. High MBL3P expression shows unfavorable associations in READ, DLBC, MESO, KICH and CESC, but favorable associations in LGG. The READ Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .003). Together, the overview and detailed table identify READ as the clearest survival context for MBL3P RNA expression.
This table summarizes MBL3P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for MBL3P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MBL3P shows lower tumor expression in LUSC, BRCA, LUAD and KICH. The LUSC box plot shows higher MBL3P RNA expression in normal versus tumor tissue (log2 FC = −0.565, t-test p < 0.001).
This table shows molecular features associated with MBL3P in patient tissues and cancer cell lines. In patient samples, MBL3P shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set.
