MBL2

Across TCGA patient cohorts, MBL2 mutation is significantly associated with the RNA expression of many other genes, with 587 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible MBL2-associated genes across cancer lineages are RNF11P2, RN7SL78P, and MIR3666. Each is linked with MBL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MBL2-to-partner and partner-to-MBL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNF11P2 grouped by MBL2-low versus MBL2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBL2→partner) and Y-score (partner→MBL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNF11P2 →	+0.045	+2.606	<.001	.002	3	3
SKCM	RN7SL78P →	+0.160	+2.099	.001	.002	3	2
LUAD	MIR3666 →	+0.438	+3.906	<.001	.001	3	2
UCEC	RNU6-1318P →	+0.401	+3.136	<.001	.008	3	2
UCEC	VAC14 →	+0.624	+3.210	<.001	.009	3	2
SKCM	RNU7-28P →	+0.212	+2.591	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 587 associations by consensus.

RNF11P2 by MBL2 expression — SKCM

Explore this box plot interactively →