MBL2

Across TCGA pan-cancer cohorts, MBL2 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated MBL2 data layer compared with 4 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MBL2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MBL2 expression acts as an unfavorable survival marker, although some lineages such as ACC and LIHC show a favorable association.

KIRC, STAD, and HNSC are the cancer types where MBL2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.552	0.691	<.001	105	view →
STAD	DFS	Tertile	All	0.282	0.451	.001	101	view →
HNSC	OS	Quartile	II,III,IV	0.290	0.664	<.001	67	view →
BRCA	OS	Quartile	II,III,IV	0.877	0.928	.007	33	view →
MESO	DFS	Tertile	II,III,IV	0.246	0.417	.014	33	view →
ACC	OS	Median	All	0.956	0.788	.012	28	view →
CHOL	OS	Quartile	II,III,IV	0.076	0.848	.002	27	view →
KIRP	OS	Quartile	II,III,IV	0.692	0.881	.010	20	view →
KICH	DFS	Tertile	III,IV	0.035	0.772	.021	18	view →
THCA	DFS	Tertile	All	0.293	0.852	.021	18	view →
LIHC	OS	Quartile	III,IV	0.806	0.287	.011	14	view →
READ	OS	Tertile	III,IV	1.000	0.321	.020	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

MBL2–KIRC (DFS)

Open the KIRC breakdown →