MATN1

Across TCGA patient cohorts, MATN1 mutation is significantly associated with the RNA expression of many other genes, with 2,031 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MATN1-associated genes across cancer lineages are RNA5SP229, RN7SKP214, and DEFB135. Each is linked with MATN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MATN1-to-partner and partner-to-MATN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP229 grouped by MATN1-low versus MATN1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MATN1→partner) and Y-score (partner→MATN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNA5SP229 →	+0.446	+2.709	<.001	.006	3	3
COAD	RN7SKP214 →	+0.799	+4.412	<.001	.002	3	2
COAD	DEFB135 →	+0.123	+4.418	.004	.008	3	2
COAD	MIR874 →	+0.457	+4.666	<.001	.005	3	2
UCEC	TAF9 →	+0.806	+3.321	<.001	<.001	3	2
UCEC	RN7SL248P →	+0.054	+3.059	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,031 associations by consensus.

RNA5SP229 by MATN1 expression — STAD

Explore this box plot interactively →