MAP3K8

Across TCGA cell cohorts, MAP3K8 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAP3K8-associated genes across cancer lineages are PRAMEF12, USP29, and DNAJC5B. Each is linked with MAP3K8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP3K8-to-partner and partner-to-MAP3K8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF12 grouped by MAP3K8-low versus MAP3K8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K8→partner) and Y-score (partner→MAP3K8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRAMEF12 →	+0.044	+3.562	.001	.002	3	1
LARGE_INTESTINE	USP29 →	+0.009	+4.000	<.001	<.001	3	1
LARGE_INTESTINE	DNAJC5B →	+0.143	+2.878	.004	.009	3	1
LARGE_INTESTINE	PDILT →	+0.005	+3.700	<.001	.009	3	1
LARGE_INTESTINE	KLF17 →	+0.007	+2.925	.007	.007	3	1
LARGE_INTESTINE	OR52N5 →	+0.038	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

PRAMEF12 by MAP3K8 expression — LARGE_INTESTINE

Explore this box plot interactively →